Examples of the Incomplete Dominance and Codominance

In all of Mendel’s experiments, he worked with traits where a single gene controlled the trait and where one allele was always dominant to the other. Although the rules that Mendel derived from his experiments explain many inheritance patterns, the rules do not explain them all. There are in fact exceptions to Mendel’s rules, and these exceptions usually have something to do with the dominant allele. One exception to Mendel’s rules is that one allele is always completely dominant over a recessive allele. Sometimes an individual has an intermediate phenotype between the two parents, as there is no dominant allele. This pattern of inheritance is called incomplete dominance. An example of incomplete dominance is the color of snapdragon flowers. One of the genes for flower color in snapdragons has two alleles, one for red flowers and one for white flowers. A plant that is homozygous for the red allele will have red flowers, while a plant that is homozygous for the white allele will have white flowers. On the other hand, the heterozygote will have pink flowers. Neither the red nor the white allele is dominant, so the phenotype of the offspring is a blend of the two parents. Another example of incomplete dominance is sickle cell anemia, a disease in which the hemoglobin protein is produced incorrectly and the red blood cells have a sickle shape. A person that is homozygous recessive for the sickle cell trait will have red blood cells that all have the incorrect hemoglobin. A person who is homozygous dominant will have normal red blood cells. And because this trait has an incomplete dominance pattern of expression, a person who is heterozygous for the sickle cell trait will have some misshapen cells and some normal cells. These heterozygous individuals have a fitness advantage; they are resistant to severe malaria. Both the dominant and recessive alleles are expressed, so the result is a phenotype that is a combination of the recessive and dominant traits. An example of a codominant trait is ABO blood types, named for the carbohydrate attachment on the outside of the blood cell. In this case, two alleles are dominant and completely expressed (designated IA and IB), while one allele is recessive (i). The IA allele encodes for red blood cells with the A antigen, while the IB allele encodes for red blood cells with the B antigen. The recessive allele (i) doesn’t encode for any antigens. An antigen is a substance that provokes an immune response, your body’s defenses against disease, which will be discussed further in the Diseases and the Body’s Defenses chapter. Therefore a person with two recessive alleles (ii) has type O blood. As no dominant (IA and IB) allele is present, the person cannot have type A or type B blood. There are two possible genotypes for type A blood, homozygous (IAIA) and heterozygous (IAi), and two possible genotypes for type B blood (IBi and IBIB). If a person is heterozygous for both the IA and IB alleles, they will express both and have type AB blood with both antigens on each red blood cell. This pattern of inheritance is significantly different than Mendel’s rules for inheritance because both alleles are expressed completely and one does not mask the other. #dominance #HealthIndustry #genetics #biology #incompleteDominance #codominance #Allele #antigen #immuneResponse #homozygous #heterozygous #MendelsRules #gene #phenotype