How SN2 Reactions Look Like (Animation) | Organic Chemistry Substitution Mechanism

👀 Let’s take a “more visual look“ (is that a pleonasm?) at SN2 reactions, geometries and molecular structures. 🚀 Thanks to all channel supporters!!! 👉 Follow me on Instagram for updates on random research, mechanism quizzes and interesting news! 00:00 Classic SN2 reaction (Williamson ether synthesis) 02:14 Sterics in SN2 reactions 02:44 Intramolecular SN2: synthesis of aldingenin C Source: J. Org. Chem. 2014, 79, 9373 | Synthesis and Structural Revision of a Brominated Sesquiterpenoid, Aldingenin C The bimolecular nucleophilic substitution (SN2 reaction) is essential to the understanding of organic chemistry fundamentals. In the SN2 reaction, a nucleophile forms a new bond to an sp3-hybridised carbon via a backside attack (electrophile). The leaving group (the group that gets substituted) dissociates in a concerted (simultaneous) manner. This differs from the step-wise SN1 reaction where the rate-determining step is dissociation of the leaving group, separate from the nucleophilic attack in SN1. Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) - Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world’s most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)