Total Synthesis of Dysiherbols A, C, and D

An organic chemistry minilecture on the Enantioselective Total Synthesis of Dysiherbols A, C, and D by Shengkun Hu and Yefeng Tang*. It utilizes a highly unusual [1,2]-Anionic Rearrangement / Cyclopropane Fragmentation reaction to form the dysiherbol framework that can be easily functionalized to synthesize multiple members of this family. SUPPORT THE CHANNEL ON PATREON: NMR Spectroscopy in music: J. New Music Res. 2021, 50:5, 487-501 Socials: References: J. Am. Chem. Soc. 2022, 144, 19521−19531 (This work) J. Nat. Prod. 2016, 79, 2, 406–411 (Discovery) Chin. J. Nat. Med. 2022, 20, 148-154 (Discovery) Angew. Chem., Int. Ed. 2021, 60, 13807−13813 (Previous synthesis/ Structural revision) Angew. Chem., Int. Ed. 2021, 60, 14915−14920 (Previous synthesis/ Structural revision) Theoret. Chim. Acta , 1977, 45, 283–300 (Quinone- alkene photocycloadditions) Tetrahedron Lett. 1988, 29,2761−2764 (Alkene isomerisation)