Robert Lefkowitz (Duke University) Part 1: Seven Transmembrane Receptors

#part-1 In the first segment of the lecture, the history of discovery in the field of seven transmembrane receptor research over the past forty years is reviewed. Highlights include overcoming initial skepticism that the receptors even existed; isolating the receptors as discrete biochemical entities and demonstrating their ligand binding and functional activating properties; discovering their seven transmembrane spanning arrangement and hom