Boost Mitochondrial Function with THESE 5 Ingredients- Energize!
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Boost Mitochondrial Function with THESE 5 Ingredients- Energize! Thomas DeLauer
ATP Overview
So our central goals are 1.) to increase the production of ATP via enhancing the activity of mitochondrial enzymes, 2.) reduce metabolic stressors (creation of free radicals), and 3.) to promote mitochondria biogenesis (defined as the process of renewal and increase of mitochondria in somatic cells).
#b16-8-15
Carnitine:
Carnitines play a significant role in the removal of accumulated toxic fatty acyl-CoA metabolites, and subsequently, assist in buffering the balance between free and acyl-CoA - meaning it might get rid of toxic compounds from the mitochondria to prevent their buildup
In addition, L-carnitine also has a protective effect both on mitochondria and in whole cells suppressing fatty acid-induced mitochondrial membrane damage and its secondary effects - those protective effects have been linked to an improved energy metabolism and the suppression of electron leakage from the ETC
Carnitine plays a significant role in the transport of fatty acids across the inner mitochondrial membrane, hence, it is essential for beta-oxidation (oxidation of fatty acids) and boosts the generation of ATP.
Proteins (especially “glutathione”):
A study published in Innovation in Aging investigated the effect of supplementing N-acetylcysteine and glycine (NAC-Gly -precursors of glutathione) on the lifetime of aging wild-type mice
32 mice were studied and matched for age and sex while consuming a supplement from the age of 65-weeks with either a standard diet (in 16 control mice) or an isocaloric-isonitrogenous diet containing NAC-Gly (in 16 study mice)
The results of the study indicated that NAC-Gly supplemented mice lived significantly longer than control mice, with a lifespan increase of 23.7%
This significant rise in lifespan was linked to improved glutathione content, reduced oxidative stress, and enhanced mitochondria fat oxidation
Overall, glutathione has a major role in the protection of the mitochondria from ROS and current research suggests that sufficient glutathione levels positively contribute to longevity. Food sources rich in glutathione include asparagus, avocado, cabbage, Brussels sprouts, spinach, and broccoli.
B vitamins:
Sufficient vitamin B intake is essential to maintain the function of numerous mitochondrial enzymes, regulate levels of metabolites and prevent metabolic diseases
B vitamins are water-soluble vitamins and act as coenzymes that are involved in several reactions linked to the generation of ATP - different B vitamins have been found to have diverse functions in energy metabolism:
Antioxidants (CoQ10 & ALA):
Two special antioxidants, Coenzyme Q10, and alpha-lipoid, were found to enhance ATP production and protect mitochondria biogenesis - the more mitochondria we possess, the less they are “overworked” and the more energy we can finally obtain
Magnesium:
In order to synthesize new mitochondria, the body needs magnesium as a cofactor to catalyse and enhance biochemical reactions
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