New brain virus

100% lethal. Time to ban this reaearch. Lethal Infection of Human ACE2-Transgenic Mice Caused by SARS-CoV-2- related Pangolin Coronavirus GX_P2V(short_3UTR) 4th January 2024 SARS-CoV-2-related pangolin coronavirus GX_P2V can cause 100% mortality in human ACE2-transgenic mice, potentially attributable to late-stage brain infection. This underscores a spillover risk of GX_P2V into humans, and provides a unique model for understanding the pathogenic mechanisms of SARS-CoV-2-related viruses. Dear Editor, Two SARS-CoV-2-related pangolin coronaviruses, GD/2019 and GX/2017, were identified prior to the COVID-19 outbreak. The respective isolates, were cultured in 2020 and 2017 the early passaged GX_P2V isolate was actually a cell culture-adapted mutant. We assessed its pathogenicity in hA