Cholesterol debate with cardiologist Dr. Alo

This week’s episode is a collaborative conversation between Dr. Paul and Dr. Mohammad Alo, board-certified cardiologist and Personal Trainer. They both offer their differing perspectives about lipids, LDL, cardiovascular disease, and seed oils. 00:00:00 Podcast begins 00:03:08 Dr. Alo’s thoughts on cardiovascular risk 00:10:18 Dr. Paul’s thoughts on cardiovascular risk & insulin resistance 00:26:38 Metabolic health of Americans 00:32:53 LDL, APOEB & atherosclerosis 00:38:53 How fasting insulin & insulin resistance relate to atherosclerosis 00:47:48 Arteries vs. veins & atherosclerosis 01:06:38 Genes vs. lifestyles & insulin resistance 01:14:23 Seed oils vs. saturated fat 01:36:38 The problems with “totality of evidence” 01:47:38 Concluding statements References: Connect with Dr. Alo: A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans An in vivo 13C magnetic resonance spectroscopic study of the relationship between diet and adipose tissue composition Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition Biomarkers of dairy fat intake, incident cardiovascular disease, and all-cause mortality: A cohort study, systematic review, and meta-analysis Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality Can linoleic acid contribute to coronary artery disease?s Cardiovascular risk factors in a Melanesian population apparently free from stroke and ischaemic heart disease Cholesterol, coconuts, and diet on Polynesian atolls: a natural experiment Changes in dietary fat intake alter plasma levels of oxidized low-density lipoprotein and lipoprotein(a) Diet and serum sex hormones in healthy men Dietary Fatty Acids and the 10-Year Incidence of Age-Related Macular Degeneration Dietary intakes of polyunsaturated fatty acids and indices of oxidative stress in human volunteers Effects of diets rich in monounsaturated fatty acids on plasma lipoproteins--the Jerusalem Nutrition Study: high MUFAs vs high PUFAs Effects of oleate-rich and linoleate-rich diets on the susceptibility of low density lipoprotein to oxidative modification in mildly hypercholesterolemic subjects High cholesterol may protect against infections and atherosclerosis Hyperinsulinemia as an independent risk factor for ischemic heart disease Hyperlipidaemia does not impair vascular endothelial function in glycogen storage disease type 1a Impact of 8-week linoleic acid intake in soy oil on Lp-PLA2 activity in healthy adults Is Butter Back? A Systematic Review and Meta-Analysis of Butter Consumption and Risk of Cardiovascular Disease, Diabetes, and Total Mortality Is glycogen storage disease 1a associated with atherosclerosis? LDL-C does not cause cardiovascular disease: a comprehensive review of the current literature Lipoprotein-associated phospholipase A2 and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies Low-Density Lipoprotein Cholesterol Corrected for Lipoprotein(a) Cholesterol, Risk Thresholds, and Cardiovascular Events Low triglycerides-high high-density lipoprotein cholesterol and risk of ischemic heart disease Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans Oxidation of low-density lipoproteins: intraindividual variability and the effect of dietary linoleate supplementation Plasma lipoprotein (a) levels in men and women consuming diets enriched in saturated, cis-, or trans-monounsaturated fatty acids Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population Premature atherosclerosis associated with monogenic insulin resistance Prevalence of Optimal Metabolic Health in American Adults Role of Physiological Levels of 4-Hydroxynonenal on Adipocyte Biology Strong increase in hydroxy fatty acids derived from linoleic acid in human low density lipoproteins of atherosclerotic patients The association between linoleic acid levels in colostrum and child cognition at 2 and 3 y in the EDEN cohort Trends and Disparities in Cardiometabolic Health Among U.S. Adults, 1999-2018 Quantification of apo[a] and apoB in human atherosclerotic lesions 4-hydroxynonenal causes impairment of human subcutaneous adipogenesis and induction of adipocyte insulin resistance Sponsors: Heart & Soil: Sign up for Animal Based Gathering 2023: Make a donation to the Animal Based Nutritional Research Foundation: Marek Health: , use code PAUL for 10% off your first lab order Calima Salt: , for a free bag of Calima Sea Salt Joovv Light Therapy: , use code PAUL for an exclusive discount Rhizal: , use code PAUL for 10% off your purchase