Hereditary Spherocytosis | Pathophysiology, Symptoms, Diagnosis and Treatment

Lesson on Hereditary Spherocytosis (Minkowski-Chauffard Syndrome): Introduction, Pathophysiology, Signs and Symptoms, Diagnosis and Treatment. Hereditary spherocytosis is an inherited hemolytic anemia, more common in Northern European populations, that is due to a mutation in a red blood cell membrane protein, such as Ankyrin. The mutation in membrane protein ankyrin leads to formation of spherocytes, red blood cells that lack central pallor, are smaller than typical red blood cells and have decreased surface area and decreased ability to deform. The decreased ability to deform leads to early removal and destruction of the red blood cells in the spleen of these patients, leading to increases in spleen size (splenomegaly), anemia, reticulocytosis and other symptoms. Hey everyone! This is a lesson the blood disorder known as hereditary spherocytosis (aka Minkowski-Chauffard syndrome). In this lesson you will learn about the epidemiology of hereditary spherocytosis, the pathophysiology and function of ankyrin protein, signs and symptoms of this disease, tests to help diagnose the disease and treatments. I hope you all find this video helpful. If you do, please like and subscribe for more videos like this one :) JJ *Subscribe for more free medical lessons* ------------------------------------------------------------------------------------------------------------- For books and more information on these topics Support future lessons (and get other cool stuff) ➜ Follow me on Twitter! ➜ Come join me on Facebook! ➜ Start your own website with BlueHost ➜ Check out the best tool to help grow your YouTube channel (it’s helped me!) ------------------------------------------------------------------------------------------------------------- Check out some of my other lessons. Medical Terminology - The Basics - Lesson 1: Fatty Acid Synthesis Pathway: Wnt/B Catenin Signaling Pathway: Upper vs. Lower Motor Neuron Lesions: Lesson on the Purine Synthesis and Salvage Pathway: Gastrulation | Formation of Germ Layers: Introductory lesson on Autophagy (Macroautophagy): Infectious Disease Playlist Dermatology Playlist Pharmacology Playlist Hematology Playlist Rheumatology Playlist Endocrinology Playlist Nephrology Playlist ---------------------------------------------------------------------------------------------------- **MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal. Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition. ---------------------------------------------------------------------------------------------------- *Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.* I am always looking for ways to improve my lessons! Please don’t hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don’t hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :) Thanks for watching! If you found this video helpful, please like and subscribe! JJ