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Carrying a defective gene doesn’t always mean death for most people. Their children might be in danger only if they get together with someone else who carries the same piece of genetic code. It is possible for them to get both recessive copies and a recessive disease. Because our gene pool is pretty big and varied, those things don’t happen very often. But if someone can only choose a partner from their own family, that chance can start to rise rapidly as generations pass down genetic material that is identical or very similar. This is called homozygosity.
Through history, all of this means that a small group of people have become very closely related. Some people got lucky and didn’t have to deal with the worst effects of their complicated family tree, while others are painful examples of why inbreeding is often seen as wrong.
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