Pedigree Chart that shows the presence or absence of a trait within a family across generations
Genotype The genetic makeup of an organism (ex: TT)
Phenotype The physical characteristics of an organism (ex: tall)
Dominant allele Allele that is phenotypically expressed over another allele
Recessive allele Allele that is only expressed in absence of a dominant allele
Autosomal trait Trait that is located on an autosome (non-sex chromosome)
Sex-linked trait Trait that is located on one of the two sex chromosomes
Homozygous Having two identical alleles for a particular gene
Heterozygous Having two different alleles for a particular gene
Problem:
Consider the following mouse pedigree in which the indicated male exhibits a distinctive rare trait. (Assume complete penetrance and that no new mutations arose in any of the individuals in this problem.)
(a) Assuming that the trait is autosomal recessive, calculate the probability that an offspring from the indicated brother-sister mating will exhibit the trait.
(b) Assuming that the trait is X-linked recessive, calculate the probability that a male offspring from the brother-sister mating will exhibit the trait.
(c) Assuming that the trait is X-linked recessive, calculate the probability that a female offspring from the brother-sister mating will exhibit the trait.
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