HIV virus infection of CD4+ T cells by means of Jurkat cells

Wolfgang Hübner et al., “Quantitative 3D Video Microscopy of HIV Transfer Across T Cell Virological Synapses,“ Science 27 March 2009: Vol. 323. no. 5922, pp. 1743 - 1747 DOI: Human immunodeficiency virus (HIV) infection leads to depletion of CD4 T cells throughout the lymphoid system. Both cell-free and cell-associated infection routes contribute to viral dissemination in vivo. In vitro, infection with cell-associated HIV can be thousands fold more efficient than infection with c